Reflecting on a successful panel discussion at the Cybersecurity Summit in New Delhi where experts explored the theme, "Building a Holistic Defensive Architecture to Secure OT, IT, ICS, and IoT Environments: A Pragmatic Approach." The session highlighted crucial strategies for mapping all endpoints, identifying risks across IT, OT, and ICS environments, and shared use cases for developing a 360-degree enterprise security architecture. The conversation provided valuable insights into how CISO leadership is driving innovation in an era marked by AI and API impacts on business governance and IT architectures.